Composition

1 ml of preparation contains active substance:

Tilmicosin – 300 mg;

Excipients: benzyl alcohol, propylene glycol, water for injection.

Pharmacological properties

АТС vet QJ01 – antibacterial veterinary drugs for systemic use. QJ01FA91 – Tilmicosin.

Tilmicosin is a semi-synthetic antibiotic of the macrolide group, which has bacteriostatic effect in low concentrations and a bactericidal effect in high concentrations, mainly on Gram-positive microorganisms and some Gram-negative microorganisms and mycoplasmas, such as Mannheimia spp., Pasteurella spp., Actinomyces spp., Fusobacterium spp., Dichelobacter spp., Staphylococcus spp., and Mycoplasma spp. as well.

Tilmicosin acts at the ribosomal level (50S-subunit); it inhibits protein synthesis in the bacterial cell. Tilmicosin has lipotropic properties, due to which it easily penetrates into organs and tissues, reaching high intracellular concentrations. This property allows you to effectively deal with respiratory diseases of animals.

Tilmicosin reaches a maximum level in the blood 1 hour after a single subcutaneous injection of a dose of 10 mg per kg of animal body weight (1 ml of Tilmicon-300 per 30 kg b.w.). A high therapeutic concentration in the tissues of the body is retained for 3 days. Tilmicosin is concentrated in the lung tissue, penetrating intracellularly into alveolar macrophages. It is excreted from the body mainly with bile, and a small amount with urine.

Administration

Treatment of cattle and sheep with interdigital necrobacillosis, hoof rot (caused by Dichelobacter nodosus and Fusobacterium necrophorum), acute mastitis (caused by Staphylococcus aureus and Mycoplasma agalactiae), as well as with respiratory diseases caused by Mannheimia haemolytica, Pasteurella multocida, and other pathogens susceptible to Tilmicosin.

Route of administration and dosages

Subcutaneously – once at a dose of 1 ml of the drug per 30 kg of animal body weight (10 mg of tilmicosin per kg b.w.).

Draw up the required dose of the drug from the vial into the syringe and disconnect the syringe from the needle, leaving the needle in the vial. If the treatment of a group of animals is planned, the needle must be left in a vial to draw the drug for subsequent injections. Fix the animal and insert another, separate needle subcutaneously, behind the scapula. Connect the syringe to the needle and inject the drug into the base of the skin fold.

When using the drug in lambs, it is important to accurately control body weight in order to avoid an overdose.

If the dose of the injected drug exceeds 20 ml for cattle or 2 ml for sheep, it should be divided and injected into some different places.

Withdrawal period

Slaughter of the animals for meat is allowed in 70 days (cattle), and in 42 days (sheep) after the last treatment. Milk for human consumption is allowed in 36 days (cattle) and in 18 days (sheep) after the last treatment. Meat and milk received before the specified time should be disposed or fed to non-productive animals, depending on the conclusion of the veterinarian.

Packaging and presentation

Glass vials closed with rubber stoppers under aluminum caps of 100 ml.

Storage conditions

Store in a dark places, out of the reach of children, at +5 to +25°.

Shelf life

24 months. Once the vial is opened: 28 days if stored in a dark place at +5 to +25° С.