Composition

1 g of the drug contains following active substances:

Ciprofloxacin (as Ciprofloxacin hydrochloride) – 100 mg;

Colistin sulfate – 10 000 000 IU.

Excipients: ascorbic acid, sodium bicarbonate, sucrose, aerosil, flavoring.

Pharmacological properties

CIPROCOLIN is a complex drug; its therapeutic impact is due to a synergistic effect of product’s active substances Ciprofloxacin and Colistin sulfate.

Ciprofloxacin belongs to the fluoroquinolones group. The mechanism of Ciprofloxacin action is to inhibit the DNA-gyrase of bacteria, thereby impeding the process of DNA replication, as well as to violate the integrity of the bacterial cell membrane, which leads to its death. Ciprofloxacin hydrochloride rapidly eliminates R-plasmids, which inhibits the development of microbial resistance to the drug.

The drug is effective against Gram-negative and Gram-positive microorganisms, and especially against Е.coli, Salmonella spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., Campylobacter spp., Pseudomonas aeruginosa, Yersinia spp., Vibrio spp., Aeromonas spp., Haemophilus spp. Such pathogens as Brucella spp., Staphylococcus spp. (including strains producing penicillinase and methicillin-resistant strains) are also susceptible to the drug, as well as Mycoplasma spp., Mycobacterium spp., Chlamydia spp.

When the drug is administered orally, Ciprofloxacin is easily absorbed in the digestive tract and getting into the blood penetrates into all organs and tissues of the body, achieving the max. concentration within 1-2 hours, the therapeutic concentration is maintained for 24 hours. Ciprofloxacin is excreted from the animal’s body with urine and bile.

Colistin sulfate is an antibiotic from the group of Polymyxins which are synthesized by aerobic spore-forming coli Bacillus polymyxa. Colistin sulfate as part of the formulation is effective against Gram-negative bacteria such as E.coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp.

Colistin sulfate binds to phospholipids of cytoplasmic membrane, increases its permeability for both intra- and external cellular components which leads to destruction of the bacterial cell.

After oral administration, Colistin sulfate is slightly absorbed from the digestive canal. Unlike low concentrations of Colistin sulfate in serum and tissues, its high and constant concentrations are always present in different parts of the digestive tract. Colistin sulfate is excreted from the body of the animal with feces.

Administration

The drug is used for therapeutic purposes in dogs and cats with acute and chronic bacterial infections, caused by pathogens susceptible to Ciprofloxacin and Colistin (infections of the digestive tract, respiratory organs, biliary tract, urogenital system; of the skin, and soft tissues, of eyes and ears, bones and joints); and with secondary infections in the background of viral diseases.

Route of administration and dosages

Before using the powder, prepare a solution as follows:

- Shake the bottle thoroughly to loosen the powder from the sides and bottom;

- Open the cap and pour drinking water at room temperature into the bottle until it reaches the neck of the bottle (100 mL);

- close the bottle, shake vigorously, and let it stand for 1 minute to complete the dissolution process;

- the preparation of the solution is accompanied by the release of carbon dioxide, so opening the bottle again will cause a hissing sound.

Measure the required amount of the resulting solution using a dosing syringe.

Administer the resulting solution orally to dogs and cats at the following doses:

0.1 g per 1 kg of body weight once daily. The treatment course is 3–5 days.

Shake the bottle vigorously before each subsequent use.

For use in pigeons and ornamental birds, mix 1 g of the solution with 1 L of water. The course of treatment is 3–5 days. During the treatment period, the birds should receive only water containing the medication. A fresh solution should be prepared daily in an amount sufficient for consumption over the course of a day.

Presentation

Plastic vials of 100 ml.

Shelf life 

36 months.

Shelf life after the first withdrawal: 28 days

Shelf life after reconstitution: 24 hours.

Storage conditions

Store in dry, dark places, out of the reach of children, at +5 to +25° С. Shelf life after dilution is 7 days.