Composition

1 ml of preparation contains active substance Toltrazuril – 50 mg; additional ingredients.

Pharmacological properties

Preparation contains an active substance Toltrazuril, derivative from group triazinetrione, of a broad spectrum against: Eimeria adenoides, E. alabamensis, E. arloingi, E. bovis, E. brunetti, E. maxima, E. meleagrimitis, E. mitis, E. necatrix, E. scarab, E. tenella, Isospora suis, Е. zuernii; and other species at all intracellular development stages.

Toltrazuril interferes with intracellular stages of Eimeria development, affecting merogony, micro- and macrogametes. It impedes process of Eimeria nucleus division and inhibits activity of mitochondria, which are responsible for respiratory metabolism.

In animals body, Toltrazuril is partially metabolized with formation of sulfone and sulfoxide derivatives. Subsequently it is almost entirely excreted with faeces in unchanged form or in form of toltrazuril sulfone or toltrazuril sulfoxide.

Product has no mutagenic, carcinogenic and teratogenic effects.

Administration

Prevention and treatment of young cattle, sheep, goats, pigs, rabbits and poultry (broilers, breeding poultry, replacement chickens, parent and broiler flocks, meat turkeys) in case of coccidiosis caused by Eimeria susceptible to Toltrazuril.

Routes of administration and dosages

The product is administered orally, either individually or to a group, mixed with drinking water, at the following doses:

• calves, lambs, and kids from 2 weeks of age – 0.3 mL per 1 kg of body weight as a single dose;

• piglets on days 3–5 of life – 0.4 mL of the drug per 1 kg of body weight, but not less than 0.5 mL and not more than 2 mL per animal as a single dose;

• rabbits from 4 weeks of age – 0.14 mL per 1 kg of body weight as a single dose;

• Poultry: 0.5 mL per 1 L of drinking water administered over 48 hours, or 1.5 mL per 1 L of drinking water administered to the birds for 8 hours over two days.

Poultry must receive water containing the drug as their sole source of drinking water. In severe cases of the disease, the treatment course is repeated after 5 days if necessary.

To achieve the maximum preventive effect and reduce the shedding of oocysts into the environment, in farms affected by coccidiosis, the drug is administered to animals before the first signs of the disease appear in the flock.

Withdrawal period

Meat: 77 days (piglets), 63 days (calves), 70 days (rabbits), 16 days (poultry) after last treatment.

Self life

24 months. After first opening – 14 days if stored in dark place at +5 to +25° С.

Storage conditions

Store in dry, dark places, out of the reach of children at +5 to +25° С.