Compositon

1 ml of the drug contains an active substance:

Doramectin – 10.0 mg.

Excipients: benzyl alcohol, ethyl oleate, butylhydroxyanisole, cottonseed oil.

Pharmacological properties

ATC vet code QP54 – endectocides, QPS4AA03 – doramectin.

DORAN is a ready-to-use sterile solution containing the active substance doramectin (10 mg/ml). Doramectin is a new substance of the avermectin group, has a wide range of systemic nematocidal, insecticidal and acaricidal effects, has larvicidal and ovicidal properties. It modulates the activity of chlorine ions in the nervous system and muscles of nematodes and arthropods. By binding to specific receptors, it increases the permeability of synaptic membranes for chlorine ions, which leads to the blockade of the activity of nerve and muscle cells of nematodes and arthropods, which causes paralysis and death of parasites.

In mammals, these receptors are localized only in the central nervous system, and doramectin does not penetrate the blood-brain barrier and is therefore safe for mammals in recommended doses.

The drug in recommended doses does not have mutagenic, teratogenic, or embryotoxic effects.

DORAN is easily absorbed from the injection site, is highly effective and has no negative effect on the animal's body. The pharmacokinetic properties of doramectin ensure long-term maintenance of therapeutic concentrations of the drug in the blood of animals and protect them from parasitic diseases and reinvasion for a long time.

Administration

Treatment and prevention of diseases of cattle, sheep, and pigs caused by nematodes and ectoparasites:

Cattle:

gastrointestinal nematodes (adults and 4^th stage larvae):

Ostertagia ostertagi (including inhibited larval stage),

O.lyrata*,

Haemonchus placei,

Trichostrongylus axei,

T.colubriformis,

Cooperia oncophora,

C.pectinata,

C.punctata,

C.surnabada (syn.mcmasteri),

Nematodirus spathiger*,

Bunostomum phlebotomum,

Strongyloides papillosus,

Oesophagostomum radiatum,

Trichuris spp*

* adults

lung helminths (adults and 4th stage larvae): Dictyocaulus viviparus;

eye helminths (adults): Thelazia spp.;

subcutaneous gadflies larvae (parasitic stages): Hypoderma bovis, H.lineatum; 

lice: Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus;

scabies mites: Psoroptes bovis, Sarcoptes scabiei.

It is also used for the treatment and prevention of diseases caused by helminths of the gastrointestinal tract Nematodirus helvetianus, lice Damalinia bovis and scabies mites Chorioptes bovis.

The drug prevents reinvasion of cattle from:

For greater efficiency, it is recommended to treat commercial livestock with DORAN when transferring to pastures and again after 8 weeks.

Sheep:

Gastrointestinal nematodes (adults and 4^th stage larvae):

Chabertia ovina (adults), 

Cooperia curticei (L₄ stage), 

C. oncophora,

Gaigeria pachyscelis,

Haemonchus contortus, 

Nematodirus battus (L₄ stage)¹, 

Ostertagia (Teladorsagia) circumcincta*, 

Oesophagostomum columbianum, 

Strongyloides papillosus, 

Trichostrongylus axeі,

Trichostrongylus colubriformis,

Trichostrongylus vitrinus, 

Trichuris spp. (adults)

*effective against L4 larval stages, even those that are naturally insensitive to benzimidazole derivatives.

¹for effective treatment and prevention of animals against adult and L4 larval stages of Nematodirus battus, a dose of 300 mcg/kg body weight is recommended;

scabies mites: Psoroptes ovis;

lung worms: Dictyocaulus filaria (adults);

nasal worms: Oestrus ovis.

Pigs:

Gastrointestinal nematodes (adults and 4^th stage larvae):

Hyostrongylus rubidus,

Ascaris suum,

Strongyloides ransomi,

Oesophagostomum dentatum,

Oesophagostomum quadrispinulatum,

lung worms: Metastrongylus spp. (adult stage);

kidney worms: Stephanurus dentatus (adult stage);

lice: Haematopinus suis,

scabies mites: Sarcoptes suis.

DORAN 1% protects pigs against invasion or re-invasion by Sarcoptes scabiei for 18 days.

Route of administration and dosage

Recommended doses of DORAN:

Cattle: 1 ml/50 kg of body weight (equivalent to 200 μg/kg), once subcutaneously in the neck area.

Sheep: 1 ml/per 50 kg of body weight (equivalent to 200 μg/kg), once intramuscularly; for diseases caused by Psoroptes ovis (sheep scabies) and Nematodirus battus (adult stage) – 1 ml/33 kg of body weight (equivalent to 300 μg/kg), once intramuscularly.

Pigs: 1 ml/33 kg of body weight or 0.3 ml/10 kg of body weight (equivalent to 300 μg/kg), once intramuscularly.

Piglets weighing up to 16 kg and less (table):

Maximum injection volume for each species:

Cattle: 5 ml at one injection site;

Sheep: 1.5 ml at one injection site;

Pigs: 2.5 ml at one injection site.

Contraindications

Hypersensitivity to the components of the drug.

Do not administer to females during lactation, if milk is used for human consumption!

Do not use the drug in pregnant cows and heifers 60 days before calving!

Withdrawal period (waiting period)

Slaughter of animals for meat is permitted after the last administration of the drug: cattle and sheep – after 70 days, pigs – after 77 days. 

Meat obtained before the specified period is disposed of or fed to non-productive animals, depending on the conclusion of a veterinarian.

Do not use in animals whose milk is intended for human consumption.

In case of forced slaughter of animals, the meat is used to feed carnivorous animals.

Storage conditions

In a dark, dry place, out of reach of children, at a temperature of 15° to 30°С.

Do not refrigerate!

Shelf life

24 months.

After drawing the first dose, the drug must be used within 28 days, provided that the drug is stored in a dark, dry place at a temperature of 15°C to 30°C.