The number in the name of the novelty is the percenta ge of the active ingredient in its composition: 500 mg of Doxycycline hyclate in 1 g of the drug.
Doxycycline is a semi-synthetic antibiotic of the tetracyclines group with a broad spectrum of action.
It has a bacteriostatic effect by inhibiting the protein synthesis of pathogens in the bundle of aminoacyl-transport RNA (tRNA) with the complex "informational RNA (iRNA) – ribosome".
Doxycycline is active against Gram-positive (Staphylococcus spp., Diplococcus pneumonia, Streptococcus spp., Bacillus anthracis, Clostridium tetani, Clostridium perfringens, Listeria monocytogens) and Gram-negative bacteria (Haemophilus influenza, E. coli, Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp., Pasteurella spp., Bordetella bronchiseptica), as well as against mycoplasmas (Mycoplasma spp.), Rickettsia spp. and Chlamydia.
A feature of Doxycycline is rapid absorption in the digestive tract of animals and poultry with a maximum concentration in the blood serum after 2-4 hours. Doxycycline penetrates well into the lungs; therefore it is effective in the treatment of respiratory infections. It binds to blood proteins by 80-90%.
Doxan-50 is developed for the treatment of pigs and calves (up to 8 weeks of age), suffering from septicemia, respiratory diseases (bronchopneumonia, pleuropneumonia, atrophic rhinitis, etc.), and the digestive tract (colibacillosis, salmonellosis), caused by pathogens susceptible to Doxycycline.
It is also used to treat chickens (broiler chickens, replacement chickens) in case of colibacillosis, salmonellosis, chlamydia, septicemia, as well as respiratory diseases caused by pathogens susceptible to Doxycycline.
The half-life is 3-12 hours (4-9 hours in cattle, 7 hours in pigs).
Doxan-50 is available in the form of a powder (yellow or light yellow) for the preparation of an oral solution. Supplied in 1 kg foil bags.
It is recommended to administer the antibiotic for 5 days. Dosage: calves – 1 g of the drug per 100 kg of body weight twice a day; pigs – 2 g per 100 kg of body weight per day; chickens (broiler chickens, replacement chickens) – 5 g of the drug per 100 kg of body weight per day.
The drug is used with drinking water in accordance with the norms of drinking, dose, and weight of animals. In general, you can focus on the following quantities: 200 g of the drug per 1000 liters of drinking water for pigs; 100 g of the drug for 500-1000 liters of drinking water for poultry (taking into account the age and species water requirements per kg b.w.). A fresh solution of the drug should be prepared daily.
Doxan-50 is registered in Ukraine. The registration certificate number: AB-09389-01-20.
