antibiotic oral solution Vials
100 ml of preparation contains following active substances:
Enroﬂoxacin – 10.0 g,
Trimethoprim – 3.0 g,
Colistin sulfate – 50 000 000 IU; Additional ingredients.
Tricolin – is a complex drug formulation; its therapeutic impact is caused by a synergistic eﬀect of product’s active substances: Enroﬂoxacin, Trimethoprim and Colistin sulfate.
Due to synergism of acti e ingredients even bacterias that are resistant to separate compounds of product show high sensitivity to Tricolin. Ingredients of Tricolin have diﬀer- ent action modes, thus blocking bacterial resistance developement.
Enroﬂoxacin is a synthetic chemotherapeutic agent belonging to ﬂuoroquinolones; it inhibits DNA synthesis in nucleus of microorganisms’ cells. Enroﬂoxacin has bactericidal action against Gram-positive and Gram-negative bacteria like Staphylococcus aureus, Enterobacteriaceae, Pasteurella spp., Brucella spp., Haemophilus spp., Actinobacillus spp., Mycoplasma spp., Chlamydia spp., Bordetella bronchisеptica, Pseudomonas aeruginosa, Salmonella spp., etc.
Trimethoprim inhibits the bacterial reductase of dihydrofolic acid (DHF). Trimethoprim is active against a broad range of microorganisms including Gram-positive and Gram-negative aerobic bacteria, Chlamydia, Pectoris (Actinomycetes), certain Mycobacteria and Protozoa, as well as many anaerobic bacteria. Mycobacterium tuberculosis, Treponema pallidum, Pseudomonas aeruginosa and Mycoplasma species – are not sensiti e, or resistant to Trimethoprim. Haemophilus parainﬂuenzae, Haemophilus ducreyi, Citrobacter freundii etc., Klebsiella oxytoca etc., Enterobacter cloacae, Serratia marcescens and other Gram-negative species are generally susceptible to Trimethoprim.
Colistin is an Antibiotic from the group of polymyxins which are synthesized by aerobic spore-forming coli Bacillus polymyxa. Colistin has a bactericidal action against Gram-negative bacteria like E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp. Colistin binds to phospholipids of the cytoplasmic membrane, increases its permeability for both intra- and external cellular components which leads to destruction of the bacterial cell.
Treatment of calves (up to 3 months of age), swine and poultry (broilers, breeders, replace- ment chicks, parent and broiler ﬂocks, and meat turkeys) in case of respiratory diseases and digestive tract infecti caused by microorganisms, susceptible to Enroﬂoxacin, Trimethoprim, Colistin and combinations thereof.
Route of administration and dosages
broilers, breeders, replacement chicks, parent and broiler ﬂocks, meat turkeys
1,0 ml per 1 L of drinking water
Once a day for 3-5 days
In case of Salmonellosis, mixed infections, chronic forms of poultry diseases: 5-7 days may be nacessary
Orally with drinking water
0.15-0.3 ml per 1 kg body weight, or 0,5-1,0 ml per 1 L of drinking water
until 3 months of age
During treatment animals should take medicated drinking water only.
Curative solution is to be prepared daily in a volume of water required for the intake by during whole day.
For meat – 7 days after last treatment. Meat reccived before this time should be disposed or feed to non-productive animals, depending on the conclusion of the veterinarian.
24 month. Medicated drinking water should be used within 24 hours.
Store in dry, dark places, out of the reach of children, at +5 to +25° С.