The clear solution from colorless to light yellow color
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1 ml of the drug contains active substance:
Tiamulin – 100.0 mg (as Tiamulin hydrogen fumarate).
Additional ingredients: benzyl alcohol, propylene glycol, propylene glycol, water for injection
ATC vet code QJ01 – Antibacterials for systemic use. QJ01XX92 – Tiamulin.
Tiamulin is a bacteriostatic semi-synthetic antibiotic of the pleuromutilin class, it acts at the ribosomal level, blocking protein synthesis in the bacterial cell.
Tiamulin acts at the 70S ribosomal level, the primary binding site is on the 50S-sublevel, and the secondary is possible in the junction places of the sublevels of 50S and 30S subunits. Tiamulin inhibits the synthesis of proteins by microbes, producing biochemical inactive initiative complexes to block the growth of the polypeptide chain.
Tiamulin is active against Gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and Gram-negative (Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter spp., Lawsonia intracellularis) bacteria; mycoplasmas (M.hypopneumoniae, M.hyorhinis, M.hyosynoviae, M.synoviae, M.gallisepticum, M.meleagridis); leptospira (Leptospira spp.); spirochaetes (Serpulina hyodysenteriae, S. innocens, S. pilosicoli, S.suis); treponema (T.hyodysenteriae) and chlamydia (Chlamydia spp.).
Tiamulin to a small extent acts against enterobacteria, such as Salmonella spp., Escherichia coli.
Tiamulin is rapidly absorbed into the blood; it is well distributed in the body and is concentrated in the lung tissue after intramuscular injection. After parenteral administration (doses of 10 and 15 mg / kg bw), the highest levels in serum were detected 2 hours after administration.
Treatment of pigs affected by dysentery, ileitis (proliferative enteropathy), spirochetal enterocolitis, enzootic bronchopneumonia, Actinobacillus pleuropneumonia, and mycoplasmal arthritis caused by pathogens susceptible to Tiamulin.
Route of administration and dosage
Intramuscularly at following doses:
Course of treatment
2.0 ml of drug per 25 kg b.w. (8 mg of Tiamulin per kg b.w.)
Only once (in severe cases repeat in 24 hours)
Enzootic bronchopneumonia and mycoplasmal arthritis
3.0 ml of drug per 25 kg b.w. (12 mg of Tiamulin per kg b.w.)
Once daily for 3 days
Pleuropneumonia, caused by Аctinobacilluspleuropneumoniae
4.0 ml of drug per 25 kg b.w. (16 mg of Tiamulin per kg b.w.)
Once daily for 3 days
The amount of drug to be administered in one injection site should not exceed 2.5 ml.
Individual hypersensitivity to Tiamulin.
Do not use in non-target animals.
Do not use drugs containing monensin, narasin, or salinomycin, at least 7 days before, during, and after treatment with Tiamulin.
Do not administer to animals with impaired liver function.
Do not use in sows in the first 5-6 weeks of gestation.
When using the drug in accordance with the instructions, side effects and complications have not been established.
In case of allergic reactions, the use of the drug is stopped, and antihistamines and symptomatic treatment are prescribed.
With a significant overdose in animals, diarrhea, anorexia, and nephrotoxic effects can be observed.
It is recommended to determine the resistance of microorganisms to Tiamulin before using the drug.
Slaughter of animals for meat is allowed in 10 days after the last treatment. Meat received before this time should be disposed or feed to non-productive animals, depending on the conclusion of the veterinarian.
Packaging and presentation
Dark glass bottles closed with rubber stoppers under aluminum cap of 10, 50 and 100 ml.
Store in dark places, out of the reach of children, at 5°С to 25°С.
24 months. After first opening – 28 days if stored at 5°С to 25°С.