TIAM 45

antibiotic powder for oral use of Tiamulin hydrogen fumarate – 45%

TIAM 45

powder for oral use

Poultry rearingPigs
TIAM 45
10 g
100 g
500 g
1 kg

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Composition

1 ml of preparation contains active substance: Tiamulin hydrogen fumarate – 450.0 mg; Additional ingredients.

Pharmacological properties

Tiamulin is a semi-synthetic antibiotic, belonging to the pleuromutilin group. Preparation is active against Gram-positive and Gram-negative pathogens (Brachyspira innocens, Brachyspirapilosicoli, Leptospira spp., Clostridium perfringens, Streptococcus spp.,

Staphylococсusspp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Pasteurella multocida, Actinomycespyogenes, Actinobacillus spp., Fusobacterium spp., Klebsiella pneumoniae, Haemophilusspp., Bacteroides spp., Campylobacter coli, Lawsonia intracellularis), as well as against Chlamydia and Mycoplasmas (Mycoplasma hyopneumoniae, Mycoplasma hyosynoviae, M.hyorhinis, M. bovis etc.). Tiamulin acts on the 70S ribosomal level, primary binding site is on the 50S-sublevel, and the secondary is possible in the junction places of the sublevels of 50S and 30S subunits. It inhibits the synthesis of proteins by microbes, producing biochemical inactive initiative complexes to prevent the growth of the polypeptide chain.

Administration

Treatment of swine in case of dysentery, as well as with respiratory and joints diseases, caused by pathogens susceptible to Tiamulin. Poultry (broilers, young growth, hens, turkeys and poults): the treatment of poultry with respiratory diseases caused by pathogens susceptible to Tiamulin.

Routes of administration and dosages

Orally via drinking water or food.

Pigs: - for the treatment of dysentery at a dose of 0.02 g of product (8.8 mg Tiamulin) per 1 kg of animal body weight per day for 3-5 days. The dose of Tiamulin is ensured by a concentration of 0.006% in drinking water; for the treatment of pigs with respiratory diseases caused by M. hyopneumoniae, P.

multocida, at a dose 0,033-0,044 g of product (15,0-20,0 mg Tiamulin) per 1 kg of animal body weight per day for 5-10 days. The dose of Tiamulin is ensured by a concentration of 0.012% -0.018% in drinking water; for the treatment of pleuropneumonia caused by A.pleuropneumoniae at a dose 0.044 g

of product (20.0 mg Tiamulin) per 1 kg of animal body weight per day for 5-7 days. The dose of Tiamulin is ensured by a concentration of 0.018% in drinking water; for the treatment of Mycoplasma arthritis in pigs caused by Mycoplasma hyosynoviae, dose is 0.044 g of product (20.0 mg Tiamulin) per 1 kg of animal body weight per day for 5-7 days. The dose of Tiamulin is ensured by a concentration of 0.018% in drinking water. To prepare a great volume of the product solution, foremost you need prepare the concentrated solution (with a maximum product concentration of 50-60 g per 1 liter of drinking water), and then it is diluted to the desired concentration. Fresh Tiamulin solutions should be prepared daily.

Table 1: Calculation of TIAM-45 concentration

Tiamulin concentration

in potable water, %

Water volume per 100 g

of TIAM-45, L

Amount of TIAM-45 per 100

liters of drinking water, g

0,06

750

13,3

0,012

375

26,7

0,018

250

40,0

0,025

180

55,6

Chickens (broilers, young growth, layer hens and breeding birds) - for the treatment of

respiratory mycoplasmosis of poultry (RMP) and alveolar sacculitis caused by M. gallisepticum

and M. synoviae, orally at a concentration of 0.025% Tiamulin in drinking water for 3-5 days.

Depending on the age of the birds, the daily dose of Tiamulin at a concentration of 0.025% in

drinking water is: for day-old chicks - 0,28-0,33 g of preparation (125-150 mg Tiamulin) per kg

body weight; for broilers at the age under 4 weeks - 0,07- 0,11 g of the drug (30-50 mg

Tiamulin) per kg of body weight; for chicks aged under 10 weeks - 0,07- 0,10 g of the drug

(30-45 mg Tiamulin) per kg of body weight; for layer hens - 0.055 g of product (25 mg

Tiamulin) per kg of body weight.

Table 2: Water quantity requirements for birds

Age of birds, weeks

4

6

8

10

12

14

16

18

20

23

Amount of drinking water per day for 1000 heads, L

60

80

100

120

140

160

180

200

220

250

Dose of the drug

for the concentration of 0.025%, g

33,3

44,4

55,6

66,7

77,8

88,9

100

111,1

122,2

138,9

Withdrawal period

For meat of animals – 4 days (pigs), 2 days (broilers, young growth, layer hens and

breeding birds) and 5 days (turkeys), after last treatment. Meat received before this time

should be disposed or fed to non-productive animals, depending on conclusion of

veterinarian. No withdrawal period for eggs.

Shelf life

36 months. After first opening – 28 days if stored in dark place at +5 to +25° С. After

dissolving in drinking water should be used within 24 hours.

Storage conditions

Store in dry, dark places, out of the reach of children, at +5 to +25 С.