powder for oral use
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1 ml of preparation contains active substance: Tiamulin hydrogen fumarate – 450.0 mg; Additional ingredients.
Tiamulin is a semi-synthetic antibiotic, belonging to the pleuromutilin group. Preparation is active against Gram-positive and Gram-negative pathogens (Brachyspira innocens, Brachyspirapilosicoli, Leptospira spp., Clostridium perfringens, Streptococcus spp.,
Staphylococсusspp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Pasteurella multocida, Actinomycespyogenes, Actinobacillus spp., Fusobacterium spp., Klebsiella pneumoniae, Haemophilusspp., Bacteroides spp., Campylobacter coli, Lawsonia intracellularis), as well as against Chlamydia and Mycoplasmas (Mycoplasma hyopneumoniae, Mycoplasma hyosynoviae, M.hyorhinis, M. bovis etc.). Tiamulin acts on the 70S ribosomal level, primary binding site is on the 50S-sublevel, and the secondary is possible in the junction places of the sublevels of 50S and 30S subunits. It inhibits the synthesis of proteins by microbes, producing biochemical inactive initiative complexes to prevent the growth of the polypeptide chain.
Treatment of swine in case of dysentery, as well as with respiratory and joints diseases, caused by pathogens susceptible to Tiamulin. Poultry (broilers, young growth, hens, turkeys and poults): the treatment of poultry with respiratory diseases caused by pathogens susceptible to Tiamulin.
Routes of administration and dosages
Orally via drinking water or food.
Pigs: - for the treatment of dysentery at a dose of 0.02 g of product (8.8 mg Tiamulin) per 1 kg of animal body weight per day for 3-5 days. The dose of Tiamulin is ensured by a concentration of 0.006% in drinking water; for the treatment of pigs with respiratory diseases caused by M. hyopneumoniae, P.
multocida, at a dose 0,033-0,044 g of product (15,0-20,0 mg Tiamulin) per 1 kg of animal body weight per day for 5-10 days. The dose of Tiamulin is ensured by a concentration of 0.012% -0.018% in drinking water; for the treatment of pleuropneumonia caused by A.pleuropneumoniae at a dose 0.044 g
of product (20.0 mg Tiamulin) per 1 kg of animal body weight per day for 5-7 days. The dose of Tiamulin is ensured by a concentration of 0.018% in drinking water; for the treatment of Mycoplasma arthritis in pigs caused by Mycoplasma hyosynoviae, dose is 0.044 g of product (20.0 mg Tiamulin) per 1 kg of animal body weight per day for 5-7 days. The dose of Tiamulin is ensured by a concentration of 0.018% in drinking water. To prepare a great volume of the product solution, foremost you need prepare the concentrated solution (with a maximum product concentration of 50-60 g per 1 liter of drinking water), and then it is diluted to the desired concentration. Fresh Tiamulin solutions should be prepared daily.
Table 1: Calculation of TIAM-45 concentration
in potable water, %
Water volume per 100 g
of TIAM-45, L
Amount of TIAM-45 per 100
liters of drinking water, g
Chickens (broilers, young growth, layer hens and breeding birds) - for the treatment of
respiratory mycoplasmosis of poultry (RMP) and alveolar sacculitis caused by M. gallisepticum
and M. synoviae, orally at a concentration of 0.025% Tiamulin in drinking water for 3-5 days.
Depending on the age of the birds, the daily dose of Tiamulin at a concentration of 0.025% in
drinking water is: for day-old chicks - 0,28-0,33 g of preparation (125-150 mg Tiamulin) per kg
body weight; for broilers at the age under 4 weeks - 0,07- 0,11 g of the drug (30-50 mg
Tiamulin) per kg of body weight; for chicks aged under 10 weeks - 0,07- 0,10 g of the drug
(30-45 mg Tiamulin) per kg of body weight; for layer hens - 0.055 g of product (25 mg
Tiamulin) per kg of body weight.
Table 2: Water quantity requirements for birds
Age of birds, weeks
Amount of drinking water per day for 1000 heads, L
Dose of the drug
for the concentration of 0.025%, g
For meat of animals – 4 days (pigs), 2 days (broilers, young growth, layer hens and
breeding birds) and 5 days (turkeys), after last treatment. Meat received before this time
should be disposed or fed to non-productive animals, depending on conclusion of
veterinarian. No withdrawal period for eggs.
36 months. After first opening – 28 days if stored in dark place at +5 to +25° С. After
dissolving in drinking water should be used within 24 hours.
Store in dry, dark places, out of the reach of children, at +5 to +25 С.