eye/ear drops, suspension
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1 ml of product contains active substances:
Ciprofloxacin (as ciprofloxacin hydrochloride) – 5 mg;
Dexamethasone (as dexamethasone sodium phosphate) – 1 mg.
Excipients: sodium hydroxide, lactic acid, benzalkonium chloride, trilon B, sodium chloride, water for injection.
CIPRONORM is a combined drug with pronounced antimicrobial and anti-inflammatory properties due to the action of ciprofloxacin and dexamethasone.
Ciprofloxacin belongs to the fluoroquinolone group. The mechanism of ciprofloxacin action is to inhibit the DNA-gyrase of bacteria, thereby impeding the process of DNA replication, as well as to violate the integrity of the bacterial cell membrane, which leads to its death. Ciprofloxacin hydrochloride rapidly eliminates R-plasmids, which inhibits the development of microorganisms’ resistance to the drug.
The product is active against Gram-negative and Gram-positive microorganisms, especially against E. coli, Salmonella spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., Campylobacter spp., Pseudomonas aeruginosa, Yersinia spp., Vibrio spp., Aeromonas spp., Haemophilus spp.; and Brucella spp., Staphylococcus spp. (including strains producing penicillinase and methicillin-resistant strains), Mycoplasma spp., Mycobacterium spp. are also susceptible to the drug.
When instilled into conjunctival sac, the drug easily penetrates into all tissues of the eye, creating a stable therapeutic concentration. Ciprofloxacin well penetrates the epithelium of the cornea and conjunctiva, thus achieving the therapeutic concentration in the eye fluid.
When instilling drug into the ear, the absorption of ciprofloxacin is insignificant. It is excreted in urine.
Dexamethasone is a synthetic glucocorticosteroid with pronounced anti-inflammatory, anti-allergic and anti-exudative activity, with a rapid onset and a slight duration of action.
Dexamethasone stabilizes the cell membranes, reduces the permeability of the blood capillaries, and shows an anti-exudative effect due to the stabilization of the lysosome membranes.
With topical application, systemic absorption is low. After instillation into the eyes, dexamethasone penetrates well into the epithelium of the cornea and conjunctiva; the therapeutic concentrations are observed in the eye fluid; when there is inflammation or damage of the mucous membrane of the eye, the penetration rate increases.
The duration of anti-inflammatory action after instillation of 1 drop of solution is from 4 to 8 hours.
A small amount of dexamethasone enters the systemic circulation. Approximately 60-70% of dexamethasone entering the circulatory system binds to plasma proteins. Dexamethasone is metabolized in the liver under the influence of cytochrome-containing enzymes; metabolites are excreted through the intestine. The half-life is an average of 3 hours.
Treatment of dogs and cats:
- In case of infectious and inflammatory diseases of the eyes and ears caused by microorganisms susceptible to ciprofloxacin;
- In case of allergic processes in the anterior part of the eye, complicated by bacterial infection;
- For prevention and treatment of inflammatory phenomena of the eyes and ears in the postoperative period.
Route of administration and dosage
The drug is instilled in the conjunctival sac or auditory canal with 1-2 drops 2-3 times daily.
The duration of treatment is usually 5-7 days. If necessary, the duration of therapy can be extended up to 2 weeks.
In the presence of abundant purulent discharge, exudates, scabs, hygienic treatment of the eyes/external auditory canal is carried out: instill 3-4 drops of the drug and remove the exudate with gauze tampons (for eyes use sterile tampons). Then instill 1-2 drops of the drug.
High individual sensitivity to the components of the drug.
Use with caution in pregnant animals.
The drug should be room temperature when applied.
Shake before use.
Plastic vials-droppers of 10 ml volume.
In dark place, out of the reach of children at 5° to 25°С.
24 months. After opening the vial 28 days if stored in a dark place at 5° to 25° C.