antibiotic of the cephalosporin series of the third generation
ceftiofur hydrochloride 5%
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1 ml of the preparation contains active substance:
Ceftiofur (as ceftiofur hydrochloride) – 50 mg.
Ceftiofur is an antibiotic of the cephalosporin series of the third generation. It has a wide spectrum of action, and is active against Gram-positive and Gram-negative bacteria, including strains producing β-lactamase, and some anaerobes, including: Escherichia coli,Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilius somnus, Actinobacillus pleuropneumoniae, Haemophilius parasuis, Salmonella cholerasuis, Streptococcus suis, Streptococcus zooepidemicus, Streptococcus equi, Pasteurella spp., Staphylococcus spp., Actynomyces pyogenes, Salmonella typhimurium, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus bovis, Klebsiela spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum and Porphyromonas asaccharolytica (Bacteroides melaninogenicus). The mechanism of bactericidal action of ceftiofur is to inhibit the functional activity of bacterial enzymes of transpeptidases and carboxypeptidase, which take part in the binding of the main component of the cell wall of pathogens – peptidoglycan, which leads to a disturbance of the osmotic balance and destruction of the bacterial cell.
Ceftiofur after parenteral administration is metabolized to form desfuroylceftiofur, which has the equivalent to ceftiofur activity against bacteria. This metabolite is inversely binds with plasma proteins and accumulates in the inflammatory focus. Ceftiofur and its metabolites are excreted from the animal organism mainly with urine and less with bile.
Cattle, poultry, pigs, sheep, goats, dogs, cats.
Treatment of cattle, sheep and goats with acute postpartum metritis, mastitis, necrobacteriosis (panaritium, hoof decay), as well as with respiratory diseases caused by microorganisms susceptible to ceftiofur.
Treatment of pigs with acute metritis, and respiratory diseases caused by microorganisms susceptible to ceftiofur.
Treatment of dogs and cats with diseases of the digestive tract (enteritis, gastroenteritis, gastroenterocolitis), respiratory diseases (bronchitis, bronchopneumonia, rhinitis) and the genitourinary system (metritis, endometritis, mastitis, agalactia, cystitis, urethritis, pyelonephritis), joints, skin and soft tissues; with acute and chronic otitis, surgical, wound, postpartum and other primary and secondary infections of bacterial etiology caused by microorganisms susceptible to ceftiofur.
ROUTE OF ADMINISTRATION AND DOSAGES
Cattle, sheep, goats: at treatment of respiratory diseases – intramuscularly at dose 1 ml of product per 50 kg body weight once daily during 3-5 days; at treatment of acute necrobacteriosis – intramuscularly at dose 1 ml of product per 50 kg body weight once daily during 3 days; at treatment of acute postpartum metritis (in 10 days after calving) – subcutaneously at dose 1 ml of product per 50 kg body weight once daily during 5 days; at treatment of mastitis – intramuscularly at dose 1-2 ml of product per 50 kg body weight once daily during 5 days.
Pigs: intramuscularly at dose 1 ml of product per 16 kg body weight once daily during 3 days.
Dogs, cats: intramuscularly at dose 0.5 ml of product per 10 kg body weight once daily during 3-5 days.
Each next injection must be done into the opposite side of the animal's body.
In the case of acute postpartum metritis, additional maintenance therapy may be necessary.
Before use, the vial should be shaken thoroughly.
The maximum recommended dose for a single injection for cattle is 10 ml of the drug; for sheep and goats, pigs and dogs – 5 ml, for cats – 1 ml.
Meat is allowed for consumption in 5 days after last treatment. Milk for human consumption is allowed without any restriction. Meat received before this time should be disposed or fed to non-productive animals, depending on conclusion of veterinarian.
Vials of glass or polymer materials with 10, 50, 100, 250 ml.
24 months. After first opening: 28 days if kept in dark place at +5° to +25°С.
Store in dark place, out of the reach of children at +5° to +25°С.