STIMULUS

сomplex of biologically active substances, immunostimulant
solution for injection

STIMULUS

Clear solution from red color to red with a raspberry or pink tint

CattlePigsDog breedingCat breedingPoultry rearingRabbits
STIMULUS
50 ml
200 ml
250 ml

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Composition

1 ml of the drug contains active ingredients:

  • sodium nucleinate – 1 mg;

  • Complex of biologically active substances*, methylparaben, propylparaben, propylene glycol, water for injection.

* Complex of biologically active substances contains:

vitamins and vitamin-like substances – D-biotin, Ergocalciferol, Choline chloride, Folic acid, Menadione, Myo-Inositol, Niacinamide, Nicotinic acid, p-Aminobenzoic acid, D-pantothenic acid, Pyridoxal hydrochloride, Pyridoxine hydrochloride, Retinol acetate, Riboflavin, α-Tocopherol phosphate, Thiamine hydrochloride;

amino acids – L-Alanine, L-Arginine hydrochloride, L-Aspartic acid, L-Cysteine, L-Cystine, L-Glutamine, L-Glutamic acid, L-Glycine, L-Histidine, L-Isoleucine, L-Leucine, L-Lysine, L-Methionine, L-Phenylalanine, L-Proline, L-Serine, L-Threonine, L-Tryptophan, L-Tyrosine, L-Valine, Adenine hemisulfate, Adenine, Adenosine, Hydroxyproline;

mineral substances – Calcium chloride, Iron nitrate, Magnesium sulfate, Potassium chloride, Sodium acetate, Sodium chloride, Sodium phosphate monosubstituted;

and others, including biologically active components: deoxyribose, ribose, glucose, cholesterol, glutathione, hypoxanthine, phenol red, tween 80, thymine, uracil, xanthine.

Pharmacological properties

ATC-vet code: QL03 – Immunostimulants.

The drug has an adaptogenic, immunostimulating, tonic effects; improves metabolism, cell metabolism, tissue regeneration due to the presence of sodium nucleinate in the drug and a balanced complex of minerals, amino acids, and vitamins.

Sodium nucleinate is an inducer of leukocyte reaction, a stimulator of intracellular metabolism, nucleic acid metabolism, especially with immunodeficiency in animals. It has anti-inflammatory activity, inhibits increased platelet aggregation.

The pharmacotherapeutic effects of the drug are based on the following mechanisms: stimulation of the processes of cell metabolism, increased biosynthesis of endogenous nucleic acids, specific proteins and enzymes; increasing the mitotic activity of bone marrow cells, acceleration of regeneration processes; increasing the energy supply of cells by stimulating the synthesis of macroergic compounds such as ATP; normalization of Nitric oxide synthase activity (NOS activity), inhibition of oxidative processes in cell membranes, stabilization of cell membranes and optimization of redox processes in tissues; increased production of interferon and stimulation of antiviral protection; activation of the pituitary-adrenal system with an increase in the level of endogenous glucocorticoids.

Administration

The drug is administered as a tonic agent in complex therapy in the treatment of cattle, horses, pigs, fur animals, dogs, cats, and poultry. Used in cases of anemia, hypovitaminosis, infectious and invasive diseases, diseases of the reproductive system, to stimulate estrus, as well as in case of poisoning; in the postoperative period; as a prophylactic in preparing animals for exhibitions, competitions, and transportation.

The drug is administered to young animals to enhance growth and improve development; as well as to other categories of emaciated and weakened animals.

Dosages

To treat cattle, horses and pigs the drug is administered subcutaneously, intramuscularly, or intravenously.

The oral administration with drinking water is possible.

Table 1. Dosage of the drug in the treatment of cattle, horses and pigs

Age group

Type of treatment

Dosage

Treatment course

Young animals

Prevention

0.5-5.0 ml/

head

1-2 times with an interval of 24-48 hours

Treatment

3.0-10.0 ml/

head

2-5 times with an interval of 24-48 hours

Adult animals

Prevention

3.0-5.0 ml/

100 kg b.w.

1-2 times with an interval of 24-48 hours

Treatment

5.0-10.0 ml/

100 kg b.w.

2-5 times with an interval of 24-48 hours

The drug is administered to poultry orally with drinking water.

Table 2. Dosage of Stimulus in the treatment of poultry

Indications

Dosage

Course of treatment

For laying hens to increase egg production and egg weight increase

Orally with drinking water, 5-50 ml/L of water

The working solution is filled into the drinking bowls at the rate of water-consuming requirements within 2 hours.

The medicated solution is to be drunk by birds within 2 hours once a day for 4-5 consecutive days. Before drinking the drug, the birds are kept without water for 1 hour

To ensure the preservation of day-old chicks

To increase the body weight gain of broiler chickens

When treating dogs, cats, fur animals, small pet birds, the drug is administered subcutaneously or intravenously.

Table 3. Dosage of the drug in the treatment of dogs, cats, fur animals, small pet birds

Indications

Dosage

Course of treatment

In case of intoxication, poisoning, bacterial and viral diseases, in the postoperative period

0.5-1.0 ml/kg b.w.

7-10 times with an interval of 24hours

When deworming the animals

Twice, 24 hours before, and 24 hours after treatment

During pregnancy to improve the condition and development of embryos

At the beginning of the first and second months of pregnancy, by courses of 10 injections with an interval of 24 hours

During the lactation period to improve milk quality

10 injections with an interval of 24 hours immediately after parturition

To improve the development and growth of young animals

Courses of 5 injections with an interval of 24 hours, starting from the second month of life. Courses can be repeated monthly up to 6 months of age

For preventive purposes in preparing animals for exhibitions, competitions and transportation

3 injections with an interval of 24 hours for 3 days before the scheduled event

In gerontology to improve the quality of life and metabolic processes as well

Courses of 10 injections with an interval of 24 hours. Courses can be repeated once every 3 months

Contraindications

Incompatibility with other drugs, feeds and feed additives is unknown.

Side effects

No.

Cautions

No.

Presentationandpackaging

Vials of glass or polymer materials of 10, 50, 100, 200, 250 ml.

Storage conditions

Store in a dark place, out of the reach of children between 2°С to 8°С.

Shelf life

18 months. After the first vial opening – 7 days if stored in a dry, dark place between 2°С to 8°С.