RELAX

injectable solution
propofol 1%

RELAX

Opalescent colloidal solution from colorless to pale yellow

Dog breedingCat breeding
RELAX
10 ml
50 ml

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Composition

1 ml of the drug contains an active substance:

Propofol – 10.0 mg.

Excipients: macrogol 15 hydroxystearate, sodium metabisulphite, trilon B, benzyl alcohol, water for injection.

Pharmacological properties

RELAX refers to the group of preparations for non-inhalation anesthesia, this is a sedative drug with ultrashort action.

Propofol – an active substance of the drug RELAX – is characterized by high lipophilicity and easily penetrates the blood-brain barrier, induces a rapid onset and short-term anesthetic effect with minimal manifestations of the stage of excitation. Within 30-60 seconds, a drug-induced sleep occurs, the development of which is due to the non-specific effect of propofol on the ion channels of the neuronal membranes of the central nervous system. The anesthetic effect after a single injection of the drug in the recommended dose is up to 8 minutes. With the support of anesthesia in the normal mode, significant accumulation of the drug is not observed. After intravenous administration, propofol binds to plasma proteins (98%), metabolized mainly in the liver by conjugation with the formation of inactive metabolites, which are excreted mainly in urine (approximately 88%).

The half-life in the initial rapid phase of the propofol distribution is 1-8 minutes, in the slow phase of the distribution it is 30-70 minutes, and in the elimination phase between 4 to 23.5 hours.

Propofol is used together with atropine, glycopyrrolate, acepromazine, xylazine, ketamine, oxymorphone, halothane and isoflurane. Pharmacological incompatibility is not observed.

Administration

RELAX is administered to dogs and cats for general short-term anesthesia (especially when a short period of animal recovery from anesthesia is required), for introductory anesthesia and maintenance of basic anesthesia. The drug can be used for introductory anesthesia in cesarean section in females.

RELAX is administered to animals in the following cases: for short anesthesia with short-term (up to 5 minutes) surgical and diagnostic procedures – once, for introductory anesthesia and maintenance of basic anesthesia by additional injections, for introductory anesthesia at inhalation anesthesia.

Dosage

To achieve a short-term anesthesia, the drug RELAX is administered intravenously at a dose calculated for the body weight of the animal, once for 10-60 seconds until an anesthetic effect is obtained.

The recommended doses, based on the animal corresponding weight, are presented in Table 1. In practice, to achieve adequate anesthesia, the dose should be adjusted, in view of the response of the animal to the administration of the drug.

When applying premedication, the dose of RELAX is reduced (Table 1).

Table 1. Dosage of the RELAX

Animal species

Type of anesthesia

Dose of RELAX is calculated based on the kg body weight of the animal

Dogs

Short-term general anesthesia:

  • without premedication

0.65 ml (6.5 mg of propofol)

  • with premedication

0.4 ml (4 mg of propofol)

Cats

Short-term general anesthesia:

  • without premedication

0.8 ml (8 mg of propofol)

  • with premedication

0.6 ml (6 mg of propofol)

For premedication, are usually used: acepromazine, oxymorphone, xylazine, according to the dosage indicated in Table 2. Other sedatives, hypnotics, opiates and/or α-2-agonists may be used as premedication drugs.

Table 2. Dosage of the drugs for premedication

Drug for premedication

Dose (mg/kg)*

Route of administration

Acepromazine

0.060

Intramuscularly, subcutaneously, intravenously

Oxymorphone

0.090

Intramuscularly, subcutaneously, intravenously

Xylazine

0.33

Intramuscularly, subcutaneously

*Doses of these drugs are lower than determined in leaflets (instructions) to them for use as mono-preparations.

General anesthesia, which lasts up to 30 minutes, is provided by induction of anesthesia with RELAX and further bolus injection of additional doses of the drug, up to a total of 2.4 ml/kg of body weight (24 mg/kg propofol).

Before inhalation anesthesia, the RELAX for inductory anesthesia is used in the same doses as for short-term anesthesia, and the primary concentration of anesthetic gas, when using RELAX, should be higher than when barbiturates are used as an inductory anesthesia.

Overdose (symptoms, emergency measures, antidotes)

An overdose of the drug can cause short-term apnea, the decrease in blood pressure, bradycardia. In these cases, use artificial ventilation, administer the drugs of symptomatic and pathogenetic therapy.

Contraindications

High individual sensitivity of the animal to the drug components (incl. in the anamnesis), severe decompensated diseases of the cardiovascular and respiratory systems.

RELAX should not be used for anesthesia in pregnant females (if the offspring is planned to be kept). The drug can be used for introductory anesthesia during cesarean section in females.

It is necessary to use the drug with caution in depleted animals, in animals with hypovolemia, kidney, liver and lung diseases.

Do not use in productive animals!

Side effects

When used in accordance with the instruction leaflet, the drug is generally well tolerated by the animals. The introduction of the drug, as well as other drugs for general anesthesia, can cause the animal to have short-term apnea, lower blood pressure, bradycardia. In these cases, use artificial ventilation, administer the drugs of symptomatic and pathogenetic therapy.

Precautions

Do not freeze!

Do not mix the drug with other medicines in the same syringe!

The drug is compatible with drugs that are used for premedication, with muscle relaxants, inhalation anesthetics, and analgesics; no undesirable pharmacodynamic interactions are indicated.

Presentation

Glass or plastic vials, volume: 10 and 50 ml.

Storage conditions

Store in a dark place, out of the reach of children at 5° to 25°С.

Shelf life

24 months. After the first vial opening – 28 days if stored in a dark place at 5° to 25° C.