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1 ml of the preparation contains the active ingredients:
Ivermectin – 1 mg;
Clotrimazole – 10 mg;
Florphenicol – 2.5 mg;
Betamethasone (as dipropionate) – 1 mg.
Additional ingredients: dimethyl sulfoxide, ethanol, polyethylene glycol, propylene glycol.
Otoflox is an antiparasitic, fungicidal, antimicrobial product; it has anti-inflammatory and antipruritic properties. Its pharmacological action is due to the properties of Ivermectin, Clotrimazole, Florfenicol and Betamethasone.
Ivermectin belongs to the group of Avermectins, which are produced by microorganisms of Streptomyces avermitilis group. In nematodes, mites, insects and larvae of gadflies Ivermectin strengthens the bond of GABA (gamma-aminobutyric acid) with special receptors on the nerve endings of the parasite by blocking the parasite innervation, causing his paralysis and death.
Ivermectin leads to the death of the following types of ectoparasites:
Otodectes, Haematopinus, Sarcoptes, Demodex, Gastrophilus, Hypoderma, Linognathus, Damalina, Solenopotes, Hаematobia, Psoroptes, Oestrus, Melophagus etc.
Clotrimazole belongs to Imidazole derivatives. Clotrimazole effect is due to violation of the synthesis of ergosterol, a component of the fungi cell membrane. As a result the structure and properties of membranes change, and cell lysis is observed. Dermatophytes, yeasts (the genus Candida, Torulopsis glabrata, Rhodotorula), fungi, pathogens of Pityriasis versicolor and erythrasma are sensitive to Clotrimazole. Furthermore, Clotrimazole acts as antimicrobial against gram-positive (Staphylococci, Streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as Trichomonas vaginalis, Malassezia furfur, Corynebacterium minussimum.
Florfenicol is thiamphenicol derivative in which the hydroxyl group is substituted with an atom of fluorine, which causes its antimicrobial activity against bacteria which synthesize acetyl transferase.
Florfenicol inhibits protein synthesis in bacteria cells. In the cytoplasm it binds to the 70S-ribosomal subunit, inhibits peptidyl transferase enzyme activity, thereby reducing the proteins synthesis in the ribosomes of corresponding bacteria.
Florfenicol has a bacteriostatic effect on gram-positive and gram-negative bacteria, namely: Fusobacterium necrophorum, Bacteroides melaninogenicus, Streptococcus spp., Staphylococcus spp., Pasteurеlla spp., Salmonella spp., Proteus spp., Pseudomonas spp., Haemophilus spp., as well as Mycoplasma spp., Rickettsia spp., Chlamydia spp.
Betamethasone belongs to the group of synthetic corticosteroid, has anti-inflammatory, antipruritic, anti-allergic, anti-proliferative effects.
OTOFLOX is indicated for the treatment of small non-productive animals (dogs, cats and decorative rabbits) with otitis of different etiologies, including those caused by ectoparasites and/or complicated by bacterial or fungal infections.
Routes of administration and dosages
Ear medications are applied after cleaning of animal’s ears and ear canals. The aim of cleaning is to remove earwax, exudates and scabs. Then the product is instilled twice daily in each ear, at a dosage as shown in Table 1, for 5-10 consecutive days depending on the clinical manifestations.
Table 1. Dosage
Number of drops
(into one ear)
Up to 1 kg
from 1 to 5 kg
from 5 to 10 kg
from 10 to 15 kg
more 15 kg
For better treatment the ear is folded lengthwise and in half, and gently massage its foundation.
Do not use this product to the sick and emaciated animals; to lactating animals, puppies, kittens and rabbits up to 10 weeks of age, as well as to animals, sensitive to the components of the product.
Do not use Ivermectin to the sensitive breeds of dogs (collies and their subtypes: sheltie, bobtail, etc.).
After animal treatment:
• avoid licking of treated area for 10 minutes;
• avoid the product intake and contact with mucous membranes.
After animals’ treatment, wash your hands thoroughly with warm soapy water.
24 months. Once opened, 28 days if stored in darkplaceat temperature from 5°C to 25°.
Indry, dark place, out of the reach of children at temperature from 5°C to 25°.