ENROCOLIN

antibiotic oral solution
enrofloxacin – 10%, colistin sulphate – 100 000 000 IU

ENROCOLIN

antibiotic oral solution

CattlePoultry rearingPigs
ENROCOLIN
10 ml
100 ml
1000 ml

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Composition

100 ml of preparation contains active substances: Enrofloxacin – 10.0 g,

Colistin sulphate — 100 000 000 IU;

Additional ingredients.

Pharmacologicalproperties

Enrocolin is a complex preparation; its therapeutic effect is caused by a synergistic effect of active ingredients of the product: Enrofloxacin and Colistin sulphate.

Enrofloxacin belongs to the group of fluoroquinolones, it inhibits synthesis of DNA in nucleus of cells of microorganisms. The product has bactericidal action against Gram- positi e and Gram-negative microorganisms (Staphylococcus aureus, Enterobacteriaceae, Pas- teurella spp., Haemophilus spp., Acti spp., Brucella spp., Bordetella bronchisepti a, Pseudomonas aeruginosa, Salmonella spp., Pasteurella spp., etc.), as well as against mycoplasmas (Mycoplasma spp.) and chlamydia (Chlamydia spp.).

Colisti is an antibioti of the group of polymyxins, which are synthesized by aerobic spore- forming coli Bacilluspolymyxa. Colisti as part of the formulati has bactericidal effect on Gram-negative bacteria (E.coli,Salmonellaspp.,Pasteurellaspp.,Haemophilusspp.,Bordetellaspp.). Colisti binds to phospholipids of the cytoplasmic membrane, enhances its permeability for intra and external cell components, which leads to destructi of bacterial cell.

The product is rapidly absorbed and penetrates into all tissues and organs of the body. Mmaximum concentration of preparation in the blood is achieved in 2 hours after application and lasts for 3-4 hours, therapeutic concentration lasts for 24 hours. Excreted in the urine, bile and feces.

Administration

Treatment of small ruminants, calves before 3 month of age, swine and poultry with respi- ratory and digestive tract diseases caused by microorganisms susceptible to Enrofloxacin and Colistin.

Main indications for use:

  • chronic respiratory disease (Mycoplasmagallisepticum,E.Coli);< >infectious synovitis (Mycoplasma synoviae);
  • aerosoculitis (M. meleagridis);
  • colibacillosis (E. Coli);
  • salmonellosis (Salmonella spp.);
  • pasteurellosis (Pasteurella multocida);
  • turkey bordetellosis (Bordetella avium);
  • erysipelas (Erysipelothrix rhusiopathiae);
  • staphylococcosis (Staphylococcus aureus);
  • chlamydiosis (Chlamydia psittaci).

Routesof administration and dosages

Animal species

Indications

Dosage

Durationof treatment

Routes

of administration

Calves under 3 months of age, pigs

Normal course of resp. & gastro-intestinal disease

0.3 ml/kg body weight

3-5 days

Orally with drinking water

Severe form of the disease

0.5 ml/kg body weight

Domestic poultry (chickens, broilers, turkeys)

Broiler and parent chicks, turkeys before 3 month; layer chicks before 5 month age

0.5-1.0 ml/L drinking water

Broiler and parent chicks, turkeys after 3 month; layer chicks after 5 month age

1.0 ml/L drinking water

In case of Salmonellosis, mixed bacterial infections, chronic diseases of poultry: treatment should last for 5-7 days.

During treatment, the birds should only receive water containing medicament. Medical solution is prepared daily in the amount of water calculated for the poultry consumption during 24 hours.

Withdrawalperiod

Meat: in 12 (calves and pigs) and 11 (poultry) days after the last treatment. Meat received before this time should be disposed or feed to non-productive animals, depending on the conclusion of the veterinarian.

Self life

24 months. Prepared water soluti of the preparati should be used within 24 hours.

Storageconditions

Store in dry, dark places, out of the reach of children, at +5 to +25° С.