Homogeneous loose powder of light yellow to yellow color.
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1 g of the drug contains an active substance:
Doxycycline hyclate – 500 mg;
Excipients: aerosil, sucrose, citric acid.
ATC vet code: QJ01 – antibacterial veterinary drugs for systemic use, QJ01AA02 – Doxycycline.
Doxycycline is a bacteriostatic antibiotic that belongs to the group of tetracyclines. It has a bacteriostatic effect by inhibiting the protein synthesis of pathogens in the bundle of aminoacyl-transport RNA (tRNA) with the complex "informational RNA (iRNA) – ribosome".
It has a broad spectrum of antimicrobial effect against Gram-positive (Staphylococcus spp., Diplococcus pneumonia, Streptococcus spp., Bacillus anthracis, Clostridium tetani, Clostridium perfringens, Listeria monocytogens) and Gram-negative bacteria (Haemophilus influenza, E. coli, Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp., Pasteurella spp., Bordetella bronchiseptica), as well as against mycoplasmas (Mycoplasma spp.), Rickettsia spp. and Chlamydia.
After oral administration, doxycycline is well absorbed in the digestive canal and reaches a maximum concentration in blood serum after 2-4 hours. Doxycycline penetrates the lungs well; therefore it is effective in the treatment of respiratory infections. It binds to blood proteins by 80-90%. The elimination half-life is 3-12 hours (4-9 hours in cattle, 7 hours in pigs). A significant part is excreted unchanged in feces, approx. 40% – in urine.
Calves (aged up to 8 months), pigs: treatment of animals with septicemia and respiratory diseases (bronchopneumonia, pleuropneumonia, atrophic rhinitis, etc.), in case of the digestive tract diseases (colibacillosis, salmonellosis) caused by pathogens, susceptible to Doxycycline.
Treatment of poultry (chickens-broilers, replacements) in case of colibacillosis, salmonellosis, chlamydiosis, septicemia, and respiratory diseases as well, caused by pathogens susceptible to Doxycycline.
Route of administration and dosage
Orally for 5 days, at following doses:
- Calves: 1 g of the drug per 100 kg b.w. (5 mg of Doxycycline hyclate per 1 kg b.w.) twice daily with drinking water;
- Pigs: 2 g of the drug per 100 kg b.w. (10 mg of Doxycycline hyclate per 1 kg b.w.) per day with drinking water;
- Poultry (chickens-broilers, replacements): 5 g of the drug per 100 kg b.w. (25 mg of Doxycycline hyclate per 1 kg b.w.) per day, with drinking water.
When using the drug with drinking water, the solution is prepared based on the required amount of drinking water (according to the norms of water consumption for certain types of animals), dose, and animals’ weight.
In general, you can focus on the following quantities:
- 200 g of the drug per 1000 litres of drinking water for pigs;
- 100 g of the drug per 500-1000 L of drinking water for poultry (taking into account age and species water requirements per kg b.w.).
A fresh solution of the drug should be prepared daily.
During the treatment, pigs and poultry should receive only water containing the drug.
Do not administer to animals with individual hypersensitivity to Doxycycline, and tetracycline group drugs.
Do not administer to animals with impaired liver and kidney function.
Do not use in adult (over the age of 8 weeks) ruminants with functionally developed forestomach (reticulorumen).
Limited use in pregnant and lactating animals.
Do not administer to laying hens, which eggs are intended for human consumption.
In some cases (in animals with hypersensitivity to tetracyclines) allergic reactions (skin rash, itching, swelling, etc.) may occur. In case of their occurrence, the drug is discontinued and desensitizing therapy is prescribed.
Doxycycline should be administered in dissolved form only, feeding undissolved drug may cause vomiting or diarrhea.
Be sure to use personal protective equipment (respirator, gloves) when working with the drug.
Do not administer concurrently with antacids, kaolin, and drugs containing Mg2+, Al3+, Ca2+, Zn2+, Fe3+ cations, as the latter bind to doxycycline and interfere with absorption.
Do not use concurrently with antibiotics that have a bactericidal effect, such as penicillins and cephalosporins.
Before using the drug, it is necessary to test for the sensitivity of microorganisms to doxycycline.
It is advisable to first test the drug on a small group of animals (7-8 heads). In the absence of side effects within 2-3 days, the drug is used in all herd.
Doxycycline is a low-toxic substance. Overdose in calves can cause symptoms of poisoning, characterized by dysfunctions of the respiratory and cardiovascular systems. The use of symptomatic therapy is recommended.
Slaughter of the animals for meat is allowed in 8 days (pigs), in 7 days (poultry), and 14 days (calves) after the last treatment. Meat received before the specified time should be disposed, or fed to non-productive animals, depending on the conclusion of the veterinarian.
PRESENTATION AND PACKAGING
Plastic bags, bags of foil materials, and polymer containers of 10 g, 50 g, 100 g, 150 g, 200 g, 250 g, 500 g; 1 kg, 2 kg, 5 kg.
SHELF LIFE AND STORAGE CONDITIONS
24 months when stored in the original package in a dry, dark place, out of the reach of children and animals, at +5 to +25° С.
Shelf life after opening (selection): 28 days if stored tightly closed in a dark, dry place out of the reach of children and animals at a temperature of 15°C to 25°C.
Do not freeze!
After dissolving in drinking water, the medicated solution should be used within 24 hours.
For veterinary use only!