COLITYL-P

powder for oral use
tylosin tartrate 5%
colistin sulfate 1 000 000 IU

COLITYL-P

homogeneous free-flowing powder from light yellow to yellow color

CattlePoultry rearingPigs
COLITYL-P
1 kg

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COMPOSITION

1 ml of preparation contains following active substances:

Tylosin tartrate– 50 mg;

Colistin sulfate – 1 000 000 IU.

Excipients: silicon dioxide, sucrose.

PHARMACOLOGICAL PROPERTIES

Colityl is a complex drug; its therapeutic impact is caused by a synergistic effect of product’s active substances Tylosin tartrate and Colistin sulfate.

Tylosin is a member of the macrolide group of antibiotics. Tylosin as part of the formulation has bacteriostatic action against Mycoplasmas (Mycoplasma spp.), Gram-positive bacteria such as Clostridium spp., Actinomyces spp., Bacillus anthracis, Corynebacterium spp., Erysipelothrix rhusiopathiae, Streptococcus spp., Staphylococcus spp., Diplococcus spp.; Gram-negative bacteria such as Pasteurella multocida, Salmonella spp., Actinobacillus spp., Fusobacterium spp., Bordetella bronchiseptica, Haemophilus spp., Bacteroides nodosus, Moraxella spp., Proteus mirabilis, as well as against Chlamydia. Action of Tylosin tartrate is in its binding to 50S ribosomal subunits of Colityl-susceptible bacteria, which leads to inhibition of polypeptides synthesis.

Colistin is an antibiotic from the group of Polymyxins which are synthesized by aerobic spore-forming coli Bacillus polymyxa. Colistin as part of the formulation has a bactericidal action against Gram-negative bacteria such as E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp. Colistin binds to phospholipids of cytoplasmic membrane, increases its permeability for both intra- and external cellular components which leads to destruction of the bacterial cell.

When administered orally, Tylosin is absorbed in the digestive tract and penetrates most organs and tissues, the therapeutic concentration of antibiotics after a single use is retained for 15-18 hours; Tylosin excreted from the body mainly as unchanged and partly as metabolites, mainly with feces and urine.

Colistin in the form of sulfate is practically not absorbed in the digestive canal, is not exposed to digestive enzymes and, as a result, creates a high concentration of antibiotics in the intestine. Colistin does not accumulate in organs and tissues, is excreted from the body, mainly in unchanged form with faeces.

ADMINISTRATION

Treatment of calves up to 3 months of age, pigs and poultry in case of respiratory diseases and digestive tract infections, caused by pathogens, susceptible to Colistin and Tylosin.

ROUTE OF ADMINISTRATION AND DOSAGES

Treatment of calves (under 3 months), pigs and poultry (chickens, broilers, turkeys) in case of the respiratory and digestive tract diseases, caused by pathogens susceptible to Colistin and Tylosin.

Orally via drinking water at doses:

Calves (up to 3 months of age), pigs – 1.0 g of product per 10 kg body weight or 0.5-1.0 g of product per 1 liter of drinking water for 3-5 days;

Poultry (chickens, broilers, turkeys) – 0.5-1.0 g of product per 1 liter of drinking water for 3-5 days.

CONTRAINDICATIONS

Individual hypersensitivity to Tylosin and Colistin.

Do not use to non-target animals.

Do not u se to hens, eggs of which are used for human consumption and ruminants with functionally developed proventriculus.

Do not use the drug simultaneously with erythromycin, clindamycin, lincomycin, chloramphenicol, penicillin.

WITHDRAWAL PERIOD

For meat is 7 days after the last treatment.

Meat received before this time should be disposed or fed to non-productive animals, depending on the conclusion of the veterinarian.

Package

Packs made of polyethylene film and polymer containers of 1 kg.

SHELF LIFE

36 months. Once the package opened, the product should be used within 28 days.

STORAGE CONDITIONS

Store in dry, dark places, out of the reach of children, at +5 to +25° С.

For veterinary use only!