Homogeneous loose powder of light yellow to yellow color.
1 g of the drug contains active substances:
Doxycycline hyclate – 250 mg;
Colistin sulfate – 2400000 IU.
Excipients: aerosil, sucrose, citric acid.
ATC vet code QJ01 – antibacterial veterinary drugs for systemic use. QJ01RA90 – tetracycline, combinations with other antimicrobial drugs.
Doxycycline is a bacteriostatic antibiotic that belongs to the group of tetracyclines. It has a bacteriostatic effect by inhibiting the protein synthesis of pathogens in the bundle of aminoacyl-transport RNA (tRNA) with the complex "informational RNA (iRNA) – ribosome".
It has a broad spectrum of antimicrobial effect against Gram-positive (Staphylococcus spp., Diplococcus pneumonia, Streptococcus spp., Bacillus anthracis, Clostridium tetani, Clostridium perfringens, Listeria monocytogenes) and Gram-negative bacteria (Haemophilus influenza, E. coli, Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp., Pasteurella spp., Bordetella bronchiseptica), as well as against mycoplasmas (Mycoplasma spp.), Rickettsia spp. and Chlamydia.
After oral administration, doxycycline is well absorbed in the digestive tract and reaches a maximum concentration in blood serum after 2-4 hours. Doxycycline penetrates the lungs well; therefore it is effective in the treatment of respiratory infections. It binds to blood proteins by 80-90%. The elimination half-life is 3-12 hours (4-9 hours in cattle, 7 hours in pigs). A significant part is excreted unchanged in feces, approx. 40% – in urine.
Colistin is an antibiotic from the group of Polymyxins which is synthesized by aerobic spore-forming Bacillus polymyxa. Colistin has a bactericidal effect against Gram-negative bacteria such as E. coli, Salmonella spp., Pseudomonas spp.
Colistin binds to phospholipids of the cytoplasmic membrane, increases its permeability for both intra- and external cellular components which leads to the destruction of the bacterial cell.
After oral administration, colistin is slightly absorbed from the digestive tract. Unlike low concentrations of colistin in blood serum and tissues, its high and constant concentrations are always present in different parts of the digestive tract. Colistin is excreted from the animal’s body with feces.
Cattle (calves aged up to 8 weeks), pigs: treatment of animals with septicemia and respiratory diseases (bronchopneumonia, pleuropneumonia, atrophic rhinitis, etc.), in case of the digestive tract diseases (colibacillosis, salmonellosis) caused by pathogens, susceptible to Doxycycline and Colistin.
Poultry (chickens-broilers, parent stocks, replacements, turkeys) – treatment of birds in case of colibacillosis, salmonellosis, ornithosis, septicemia, as well as respiratory diseases caused by pathogens susceptible to Doxycycline and Colistin.
ROUTE OF ADMINISTRATION AND DOSAGES
Orally at following doses:
- Cattle (calves aged up to 8 weeks): 2 g of the drug per 100 kg b.w. (5 mg of Doxycycline hyclate and 48000 IU of Colistin sulfate per 1 kg b.w.) twice daily with drinking water for 3-5 days;
- Pigs: 4 g of the drug per 100 kg b.w. (10 mg of Doxycycline hyclate and 96000 IU of Colistin sulfate per 1 kg b.w.) per day with drinking water for 3-5 days;
- Poultry (chickens-broilers, parent stocks, replacements, turkeys): 10 g of the drug per 100 kg b.w. (25 mg of Doxycycline hyclate and 240000 IU of Colistin sulfate per 1 kg b.w.) per day, with drinking water for 5 days.
To prepare the solution, the required amount of drinking water, preferably warm, is poured into a small container, and the drug is poured out in small portions, stirring continuously, until the powder is completely dissolved (ratio: 0.2-0.4 kg of the drug per 10 litres of drinking water). The resulted concentrate is immediately added to the required amount of drinking water.
When using the drug with drinking water, the solution is prepared based on the required amount of drinking water (according to the norms of water consumption for certain types of animals), dose, and animals’ weight.
In general, you can focus on the following quantities:
- 400 g of the drug per 1000 litres of drinking water for pigs;
- 200 g of the drug per 500-1000 l of drinking water for poultry (taking into account age and species water requirements per kg b.w.).
A fresh solution of the drug should be prepared daily. During treatment, pigs and poultry should only drink water containing the drug.
Do not administer to animals with individual hypersensitivity to tetracyclines and polymyxins class drugs.
Do not use simultaneously with antibiotics of the penicillin group, cephalosporins, quinolones, lincomycin, and cycloserine.
Do not administer to animals with impaired liver and kidney function.
Limited use in pregnant and lactating animals.
Do not administer to laying hens, whose eggs are intended for human consumption.
Do not use in ruminants with functionally developed forestomach (reticulorumen).
In some cases (in animals with hypersensitivity to tetracyclines and polymyxins class drugs) allergic reactions (skin rash, itching, swelling, etc.) may occur. In case of their occurrence, the drug is discontinued and desensitizing therapy is prescribed.
High doses or prolonged use of the drug can cause neurotoxic effects.
Be sure to use personal protective equipment (respirator, gloves) when working with the drug.
Do not use simultaneously with antacids, kaolin, drugs containing unsaturated fatty acids, ammonium compounds, as well as with drugs containing Mg2+, Al3+, Ca2+, Zn2+, Fe3+ cations, as the latter bind to Doxycycline and interfere with absorption and also inhibit the effect of Colistin.
It is advisable to first test the drug on a small group of animals (7-8 heads). In the absence of adverse effects within 2-3 days, the drug is used in all herds.
Overdose in calves can cause symptoms of poisoning, characterized by dysfunctions of the respiratory and cardiovascular systems. The use of symptomatic therapy is recommended.
Slaughter of the animals for meat is allowed in 8 days (pigs), in 7 days (poultry), and 14 days (calves) after the last treatment. Meat received before the specified time should be disposed or fed to non-productive animals, depending on the conclusion of the veterinarian.
PRESENTATION AND PACKAGING
Bags of polymer foil materials of 50 g, 100 g, 150 g, 200 g, 250 g, 500 g; 1 kg, 2 kg, 5 kg.
24 months, when stored in the original package.
Once the bag is opened: 28 days if stored tightly closed in a dark, dry place, out of reach of children and animals at 15° to 25°С.
After dissolving in drinking water, the medicated solution should be used within 24 hours.
Store in a dry, dark place, out of the reach of children and animals, at 5° to 25°С.
Do not freeze!
For veterinary use only!