antiparasitic injectable solution
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1 ml of preparation contains active substance: Ivermectin – 8 mg, Closantel – 100 mg (equivalent to 108,9 mg Closantel Sodium Dihydrate); additional ingredients.
CLOSIVERON is a combined preparation of broad antiparasitic activity, which is composed of Ivermectin and Closantel. The components of product act synergistically by inhibiting activity of enzymes, breaking metabolic processes in body of parasites.
Ivermectin belongs to compounds which are produced by microorganisms of group Streptomyces avermitilis. Ivermectin has high eﬃciency, broad spectrum of action (insecticidal, acaricidal and nematicidal activity) and has relatively low toxicity. Ivermectin stimulates secretion of gamma-aminobutyric acid (GABA) in presynaptic neurons, which binds to speciﬁc receptors of nerve endings by increasing membrane permeability to chloride ions and inhibits transmission of neuromuscular pulses. This causes paralysis and death of the parasites.
Maximum concentration in the blood is achieved approximately in 4 hours. It is characterized by a high degree of binding to plasma proteins (93%). Penetrates into many tissues, in small amounts - into milk. Does not pass through blood-brain barrier. It is metabolized in liver, and excreted mainly with faeces. Half-life is 12-16 hours.
Closantel is an antiparasitic agent structurally derived of salicylanilides, it has a lasting impact on endo- and ectoparasites. Closantel inhibits phosphorylation process (formation of ATP) in the body of parasite due to intervention in processes of transporting electrons, altering energy metabolism, which leads to death of a parasite. Closantel is eﬀective against trematodes (Fasciola gigantica, Fasciola hepatica); gastrointestinal nematodes (Bunostomum spp., Haemonchus contortus, Oesophagostomum radiatum); gadﬂy larvae (Hypoderma bovis, Hypoderma lineatum, Oestrus ovis); scabies mites (Psoroptes spp.) in cattle, sheep and goats. Closantel is quickly absorbed after subcutaneous or intramuscular administration.
Maximum concentration in blood of sheep is reached in 8-24 hours after administration, in blood of cattle in 24-48 hours. The half-life is about 12-15 days.
The highest concentration of Closantel is detected in liver, kidney and adipose tissue. Closantel intensively binds to plasma proteins and practically not metabolized in the body of animals; more than 90% of it is excreted unchanged with faeces. The drug is quickly absorbed from the injection site and penetrates into organs and tissues of animals. The therapeutic concentration of the drug in animals is maintained for 10-12 days. The product in therapeutic doses has no embryotoxic and teratogenic eﬀects.
Treatment of cattle aﬀected by:
nematodes (adult and larval stages) – Ostertagia spp., Haemonchus placei, Cooperia spp., Oesophagostomum radiatum, Trichostrongylus spp., Strongyloides papillosus, Bunostomum phlebotomum, Toxocara vitulorum, Trichuris spp, Dictyocaulus viviparus (adult stages), Nematodirus spp.;
- trematodes – Fasciola spp.;
- gadﬂy larvae – Hypoderma bovis. Hypoderma lineatum;
- scabies mites – Psoroptes bovis, Sarcoptes bovis;
- lice – Haematopinus eurysternus.
Treatment of sheep and goats aﬀected by:
- nematodes (adult and larval stages) – Ostertagia spp., Haemonchus contortus, Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Nematodirus spp., Bunostomum spp., Chaberta ovina, Chaberta ovis, Trichuris ovis; Dictyocaulus ﬁlaria, Protostrongylus spp.;
- trematodes – Fasciola hepatica;
- gadﬂy larvae – Oestrus ovis;
- scabies mites – Psoroptes ovis, Sarcoptes ovis;
- sheep keds – Melophagus ovinus.
Routes of administration and dosages
1 ml per 50 kg body weight, subcutaneously
Helminthiasis and enthomosis – single administration.
Mites – twice with an interval of 5-7 days
0.5-0.6 ml per 25 kg body weight, subcutaneously
Slaughter of cattle and sheep for meat is allowed in 28 days after the last treatment. In the case of forced slaughter of animals before the deadline their meat could be fed to carnivorous animals.
24 months. After ﬁrst opening – 14 days if stored in dark place at +5 to +25° С.
Store in dry, dark places, out of the reach of children at +5 to +25° С