CIPROCOLIN

сiprofloxacin 1%
сolistin sulfate – 10 000 000 IU

CIPROCOLIN

powder to make a solution for oral administration

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Description

Uniform powder of white or light yellow color, after dissolution a solution of light yellow color with opalescence is obtained.

Composition

1 vial of the drug contains following active substances:

Ciprofloxacin (as Ciprofloxacin hydrochloride) – 1000 mg;

Colistin sulfate – 10 000 000 IU.

Excipients: ascorbic acid, sodium bicarbonate, sucrose, aerosil, flavoring.

Pharmacological properties

CIPROCOLIN is a complex drug; its therapeutic impact is due to a synergistic effect of product’s active substances Ciprofloxacin and Colistin sulfate.

Ciprofloxacin belongs to the fluoroquinolones group. The mechanism of Ciprofloxacin action is to inhibit the DNA-gyrase of bacteria, thereby impeding the process of DNA replication, as well as to violate the integrity of the bacterial cell membrane, which leads to its death. Ciprofloxacin hydrochloride rapidly eliminates R-plasmids, which inhibits the development of microbial resistance to the drug.

The drug is effective against Gram-negative and Gram-positive microorganisms, and especially againstЕ.coli, Salmonella spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., Campylobacter spp., Pseudomonas aeruginosa, Yersinia spp., Vibrio spp., Aeromonas spp., Haemophilus spp. Such pathogens as Brucella spp., Staphylococcus spp. (including strains producing penicillinase and methicillin-resistant strains) are also susceptible to the drug,as well as Mycoplasma spp., Mycobacterium spp., Chlamydia spp.

When the drug is administered orally, Ciprofloxacin is easily absorbed in the digestive tract and getting into the blood penetrates into all organs and tissues of the body, achieving the max. concentration within 1-2 hours, the therapeutic concentration is maintained for 24 hours. Ciprofloxacin is excreted from the animal’s body with urine and bile.

Colistin sulfate is an antibiotic from the group of Polymyxins which are synthesized by aerobic spore-forming coli Bacillus polymyxa. Colistin sulfate as part of the formulation is effective against Gram-negative bacteria such as E.coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp.

Colistin sulfate binds to phospholipids of cytoplasmic membrane, increases its permeability for both intra- and external cellular components which leads to destruction of the bacterial cell.

After oral administration, Colistin sulfate is slightly absorbed from the digestive canal. Unlike low concentrations of Colistin sulfate in serum and tissues, its high and constant concentrations are always present in different parts of the digestive tract. Colistin sulfate is excreted from the body of the animal with feces.

Administration

The drug is used for therapeutic purposes in dogs and cats with acute and chronic bacterial infections, caused by pathogens susceptible to Ciprofloxacin and Colistin (infections of the digestive tract, respiratory organs, biliary tract, urogenital system; of the skin, and soft tissues, of eyes and ears, bones and joints); and with secondary infections in the background of viral diseases.

Route of administration and dosages

Before using the drug, a solution is prepared from the powder. To do this, 100 ml of drinking water of room temperature is poured into the powder vial (up to the mark) and shaken vigorously until the powder is completely dissolved.

The required amount of the resulting solution is drawn up with a dosing syringe.

The resulting solution is administered to dogs and cats orally in doses: 1 ml per 1 kg of animal body weight once daily. The course of treatment is 3-5 days.

Before each subsequent use, the vial is shaken vigorously.

Precautions

Not recommended for administration to:

  • puppies and kittens before the end of the growth period due to the risk of cartilage damage;
  • animals with severe cartilage development disorders;
  • animals with lesions of the nervous system, which are accompanied by convulsions;
  • females during pregnancy and lactation.

Do not administer to animals with individual hypersensitivity to the components of the drug.

Do not administer together with NSAIDs, antibiotics of macrolides group, tetracycline, and chloramphenicol.

Presentation

Plastic vials of 100 ml.

Shelf life

36 months.

Storage conditions

Store in dry, dark places, out of the reach of children, at +5 to +25° С. Shelf life after dilution is 7 days.