The new product is intended for use in poultry, as well as in pigs and calves in pathological conditions accompanied by hyperthermia caused by heat stress, inflammatory or pain syndrome of mild and moderate intensity
BIOTESTLAB Company introduced to the market the drug THERMONORM with an active substance acetylsalicylic acid, for use in pathological conditions, accompanied by hyperthermia in poultry (broiler chickens, breeding chickens, replacement chickens), pigs, and calves.
THERMONORM is available in powder form (of white or light gray color). 1 g of the drug contains 700 mg of acetylsalicylic acid. It is supplied in 1 kg foil bags.
The main goal of using THERMONORM is to prevent the negative impact of heat stress on the body of poultry and animals.
Valeria Kilimenko, Head of the department for the introduction of veterinary medicines, BIOTESTLAB:
— It's no secret that birds and animals are hard to tolerate high temperatures. This is due to their physiology. For example, in the body of birds there are no sweat glands, the cardiovascular reaction is weak, there are thermo-receptors only in the skin, brain, and tongue. As the temperature rises, the birds begin to breathe faster: the number of cycles increases from 22-25 to 250 or more per minute.
To evaporate one gram of water, up to 540 calories of energy are expended. Birds move less, eat less: it has been proven that for every degree above 20°C, broiler feed consumption is reduced by 1.5%. Digestion problems occur. At a temperature of 35°C, the mass of the small intestine decreases by 20-23%, the absorbing surface of the villi – by 19%, the activity of digestive enzymes – by 60%.
The acidity and bactericidal function of gastric juice decrease, the balance between beneficial and pathogenic microflora is disturbed, and PSE (soft muscle tissue) syndrome develops. This results in poor feed conversion and reduced broilers growth, decreased egg production, and egg quality in layers. Ultimately, if heat stress is not addressed, an increase in overall body temperature leads to venous congestion. And this is the cause of death from asphyxia or cardiovascular failure.
Acetylsalicylic acid, which is part of THERMONORM, provides to lower body temperature by suppressing the areas of the brain and central nervous system that regulate the corresponding processes in the body. In addition, the antiplatelet effect of acetylsalicylic acid thins the blood, dilates blood vessels, and slows down the formation of blood clots in the vascular bed, minimizing the ability of platelets to stick together.
The use of THERMONORM during the hot period contributes to the normal functioning of the cardiovascular system, preventing the massive death of birds or animals from heart diseases (ischemia, heart attack, etc.), and also normalizes the functioning of the gastrointestinal tract, immune, and reproductive systems of the body.
Another direction of using the drug is for various inflammatory processes of non-infectious genesis, pain syndrome, with pronounced post-vaccination complications: acetylsalicylic acid effectively fights inflammatory processes, inhibiting the cyclooxygenase activity, as a result of which the energy does not flow to the foci of inflammation, lowers the temperature, and relieves pain.
THERMONORM contains sodium bicarbonate and aerosil as excipients. The first substance ensures good solubility of the drug in the water of various hardness, maintains the stability of the solution for 24 hours. Aerosil prevents caking and lumping during a long period of storage.
When developing THERMONORM, we took into account the factor of saving labor costs for personnel. Sodium bicarbonate, when wet in water, causes the release of carbon dioxide, which leads to a rapid loosening of powder conglomerates, accelerates the dissolution of the drug. In this case, there is no need to constantly monitor the solution, and stir it. Due to Aerosil, the drug does not cake during the entire storage period – for two years, remains stable after opening the package for 28 days. All this ensures a positive result due to the complete dissolution of the powder and the entry of the active substance into the body of a bird or animal.
THERMONORM is administered orally for 3-5 days. Dosage: 1 g of the drug per 7 kg of animal body weight (100 mg of acetylsalicylic acid per kg of b.w.) per day with drinking water or individually; 0.3-0.6 kg per 1000 liters of water for poultry; 1.5 kg per 1000 l of water for pigs. A fresh solution of the drug must be prepared every day.